Like oxazepam, it does not require hepatic oxidation, but only hepatic glucuronidation into lorazepam-glucuronide.

Ativan can cause side effects that may impair your thinking or reactions. A large-scale, nationwide, U. It is sometimes used in chemotherapy as an adjunct to antiemetics for treating anticipatory nausea and vomiting, i. It is given before a general anaesthetic to reduce the amount of anaesthetic agent required, or before unpleasant awake procedures, such as in dentistry or endoscopies, to reduce anxiety, to increase compliance, and to induce amnesia for the procedure. gov/buyonlineguideBefore taking AtivanDo not use this medication if you have narrow-angle glaucoma, or if you are allergic to Ativan or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), or oxazepam (Serax). You may also have seizures or withdrawal symptoms when you stop using Ativan. On regular administration diazepam will, however, accumulate more, since it has a longer half-life and active metabolites with even longer half-lives. Richards. The drug was developed by President of Research, D. edit ChemistryLorazepam is synthesized according to a scheme containing some of the same elements for the synthesis of chlordiazepoxide and oxazepam.