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This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. It is the classic way in which acute alcohol intoxication may affect a person. But its poor lipid solubility and high degree of protein binding (85-90% ) mean that lorazepam's volume of distribution is mainly the vascular compartment, causing relatively prolonged peak effects. The injectable solution comes in 1 mL ampoules containing 2 mg or 4 mg lorazepam. Do not use Ativan if you are pregnant. edit Detection in body fluidsLorazepam may be quantitated in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest or to assist in a medicolegal death investigation. Lorazepam is more effective than diazepam in the treatment of status epilepticus. * Drug and alcohol dependence – There is an increased risk of abuse of lorazepam. Patients at first experience drastic relief from anxiety and sleeplessness, but symptoms gradually return, relatively soon in the case of insomnia but more slowly in the case of anxiety symptoms. Adverse effects are more common in the elderly, and they appear at lower doses than in younger patients.