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Lorazepam also has abuse potential; the main types of misuse are for recreational purposes or continued use against medical advice. You may need to use less and less before you stop the medication completely. Lorazepam is considered to be a short-acting drug which, similar to other benzodiazepines, exerts its therapeutic as well as adverse effects via its interaction at benzodiazepine binding sites, which are located on GABAA receptors in the central nervous system. Lorazepam-glucuronide is eventually excreted by the kidneys, and, because of its tissue accumulation, it remains detectable - particularly in the urine - for substantially longer than lorazepam. Hydrolysis of thee above product forms the desired product lorazepam. Catatonia due to abrupt or too rapid withdrawal from benzodiazepines, as part of the benzodiazepine withdrawal syndrome, should also respond to lorazepam treatment. In medicinal form, lorazepam is mainly available as tablets and a solution for injection, but, in some locations, it is also available as a skin patch, an oral solution, and a sublingual tablet. What happens if I miss a dose?Take the missed dose as soon as you remember. * Acute narrow-angle glaucoma – Lorazepam has pupil-dilating effects, which may further interfere with the drainage of aqueous humour from the anterior chamber of the eye, thus worsening narrow-angle glaucoma. The combination with alcohol increases these impairments.