Keep the medication in a secure place where others cannot get to it.

Benzodiazepines, including lorazepam, have been found to increase the risk of falls and fractures in the elderly. However, if mechanical ventilation becomes necessary, lorazepam may be used to facilitate deep sedation. C. Due to its poor lipid solubility lorazepam is absorbed relatively slowly by mouth and is unsuitable for rectal administration. Among benzodiazepines, lorazepam has a relatively high addictive potential. Similarly renal disease has minimal effects on lorazepam levels. The magnitude and duration of lorazepam effects are dose-related, meaning that larger doses have stronger and longer-lasting effects. If any benzodiazepine has been used long-term, the recommendation is a gradual dose taper over a period of weeks, months or longer, according to dose and duration of use, degree of dependence and the individual. Pure lorazepam is an almost white powder that is nearly insoluble in water and oil. Toxicity from propylene glycol has been reported in the case of a patient receiving a continuous lorazepam infusion.