Potent benzodiazepines such as lorazepam, alprazolam and triazolam have the highest risk of causing a dependence.

To minimise the risk of physical/psychological dependence, lorazepam is best used only short-term, at the smallest effective dose. Intravenous diazepam or lorazepam are first-line treatments for convulsive status epilepticus. government study of pharmaceutical-related ED visits by SAMHSA found that sedative-hypnotics in the United States are the pharmaceuticals most frequently used outside of their prescribed medical purpose, with 35% of drug-related emergency room visits involving sedative-hypnotics. Regular lorazepam use during late pregnancy (the third trimester), carries a definite risk of benzodiazepine withdrawal syndrome in the neonate. government study of pharmaceutical-related ED visits by SAMHSA found that sedative-hypnotics in the United States are the pharmaceuticals most frequently used outside of their prescribed medical purpose, with 35% of drug-related emergency room visits involving sedative-hypnotics. Similarly renal disease has minimal effects on lorazepam levels. Tell your doctor if you regularly use any of these other medicines. However, phenobarbitol has a superior success rate compared to lorazepam and other drugs, at least in the elderly. Sedation is the most complained-of side effect. Similarly renal disease has minimal effects on lorazepam levels.