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5. Sustained repetitive firing seems to get limited, by the benzodiazepine effect of slowing recovery of sodium channels from inactivation in mouse spinal cord cell cultures. Lorazepam (initially marketed under the brand names Ativan and Temesta) is a high-potency short-to-intermediate-acting 3-hydroxy benzodiazepine drug that has all five intrinsic benzodiazepine effects: anxiolytic, amnesic, sedative/hypnotic, anticonvulsant and muscle relaxant. Tell your doctor about any unusual or bothersome side effect. Lorazepam serum levels are proportional to the dose administered. * Comorbid psychiatric disorders – Increased risk of dependence and paradoxical adverse effects edit Tolerance and dependenceDependence typified by a withdrawal syndrome occurs in approximately one third of individuals who are treated for longer than 4 weeks with a benzodiazepines. Tell your doctor about any unusual or bothersome side effect. Therefore, impaired liver function is unlikely to result in lorazepam accumulation to an extent causing adverse reactions. J. This is because the brain has spare benzodiazepine drug receptor capacity, with single, clinical doses leading only to an occupancy of some 3% of the available receptors.