It is also used as adjunct therapy for cyclic vomiting syndrome.

Other classical benzodiazepines include diazepam, clonazepam, oxazepam, nitrazepam, flurazepam, bromazepam and clorazepate. * Ataxia – This is a neurological clinical sign, consisting of unsteady and clumsy motion of the limbs and torso, due to failure of gross muscle movement coordination, most evident on standing and walking. S. Lorazepam is present in breast milk, so caution must be exercised about breast feeding. This medication can increase the effects of alcohol. Benzodiazepine treatment should be discontinued as soon as possible via a slow and gradual dose reduction regimen. The mechanism of tolerance to benzodiazepines is complex and involves GABAA receptor downregulation, alterations to subunit configuration of GABAA receptors, uncoupling and internalisation of the benzodiazepine binding site from the GABAA receptor complex as well as changes in gene expression. Tell your doctor if you regularly use any of these other medicines. Call your doctor at once if you have any of these serious side effects:* confusion, depressed mood, thoughts of suicide or hurting yourself; * hyperactivity, agitation, hostility; * hallucinations; or * feeling light-headed, fainting. Wyeth's original patent on lorazepam is expired in the United States but the drug continues to be commercially viable.